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and Robert G
where m1Ψ provides stronger suppression of innate immune responses and supports robust protein expression in vivo
and Nahum Sonenberg
" Molecular Therapy Nucleic Acids 12 (2018): 530-542
position: relative
DMT-2'-F-dG(dmf)-CE Phosphoramidite IVT and Robert GDMT 2 F dG(dmf) CE Phosphoramidite is a 2' fluoro (2' F) phosphoramidite monomer used for solid phase oligonucleotide synthesis. It contains a 2' F modification on the sugar of deoxyguanosine (dG) with dimethylformamidyl (dmf) base protection, a 5 dimethoxytrityl (DMT) group for 5' hydroxyl protection, and a cyanoethyl (CE) protecting group on phosphite. Synthesis of RNA oligonucleotides using 2' F phosphoramidite increases the nuclease resistance and